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Adverse events: There were no unexpected safety findings, however, gastrointestinal (GI) side effects were a main cause of treatment discontinuation, which occurred in 16.6% of patients in the semaglutide group vs

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The use of semaglutide in patients with diabetes was associated with a significantly increased risk for nonarteritic anterior ischemic optic neuropathy (NAION) compared with those taking drugs for diabetes that belong to other classes of medication.

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But the drug has been around longer than that.