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Using a combination of chemogenetic, optogenetic, and pharmacological methods in wild-type and Glp-1Rdeficient mice, the authors delineated an NTS MHb IPN pathway responsible for nicotine avoidance

Dynamics of CNS barriers: evolution, differentiation, and modulation

423 Furthermore, the study emphasized that neurons in specific brain regions, such as the hindbrain and hypothalamus, co-express GLP-1R along with 1-adrenergic and -opioid receptors, suggesting a localized mechanism within the CNS that could coordinate peripheral anti-inflammatory responses