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In those high risk patients, albiglutide significantly reduced MACE compared to placebo, and unlike semaglutide in SUSTAIN-6 trial this difference was most prominent in reducing the rate of myocardial infarction (39, 41, 42)
Optimizing the substituent on the benzimidazole nitrogen proved a fruitful approach to improve potency without detrimentally impacting physiochemical properties, with smaller, more polar groups preferred
Not recommended in pregnancy
They must be prescribed and monitored by a qualified healthcare professional
