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But what it does mean is that shortly everyone will be put onto GLP drugs before even considering diet I see a lot of anecdotal reports of anhedonia and I suspect if a patient already has issues with their dopaminergic system, reward motivation, etc, that they might not be the best candidates for GLP-1 agonists for depression treatment as they can cause anhedonia even in low doses by affecting brain reward pathways and blunting dopamine signaling, often reported as emotional flatness

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On the other hand, with drugs such as Wegovy, some of the underlying metabolic imbalances may persist

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