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Retatrutide, a triple-hormone agonist, has been shown in Phase 2 trials to be extremely effective in inducing weight loss in a dose-dependent manner.42 Given the potential extraordinary economic and composite health benefits to the individual and population, it seems likely that the area of Bariatric Pharmacology will continue to expand

Front Endocrinol 8:6 Christensen M, Knop FK, Vilsbll T, Holst JJ (2011) Lixisenatide for type 2 diabetes mellitus

GLP-1 Native GLP-1 reduces adipogenesis via ERK-inhibition, downregulating PPAR , LPL , C/EBP and FABP4 [12, 22, 23, 31]

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Overall, triggering the activation of BAT or inducing the browning of WAT offers a highly effective approach to obesity treatment [16,19]