why are glp 1 drugs so expensive GLP-1 Costs Explained: Managing Coverage Challenges And THIS is why GLP-1

Barriers to translation There has yet to be a full accounting of the promise and price of GLP-1R agonists --only time will tell

The results of a transcriptomic analysis obtained from a mouse model also revealed that the stimulation of GLP-1 receptor by high doses of exendin-4 upregulates IGF-1R typically in pancreatic islets, thus reinforcing the concept that activating the IGF-1R/IRS-2/Akt pathway mediates the prevention of -cell loss under the control of incretins (40)

Dose adjustments or therapy changes based on response and tolerability

Perley, M

D., Dashi G., Maslov I., et al., Trends in Antidiabetic Drug Discovery: FDA Approved Drugs, New Drugs in Clinical Trials and Global Sales, Frontiers in Pharmacology 12 (2022): 12, 10.3389/fphar.2021.807548