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GLP-1 analogs are effective in the PCOS population for weight loss, but PCOS patients who wish to become pregnant are not indicated for this kind of treatment

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Animal studies have shown potential embryotoxic effects, and although human data are limited, the precautionary principle applies

Combine these healthy dietary choices with regular physical activity, such as walking, strength training, or yoga, to enhance metabolism, improve insulin sensitivity, and achieve sustainable results

Thus, although the increase in CNS-GLP-1R signaling is sufficient to activate BAT thermogenesis, whether this regulation is necessary for the contribution of BAT thermogenesis to the control of energy balance, or to the body weight lowering effects of GLP-1 based therapies still requires further investigation