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A serious AE was defined as an AE resulting in any of the following: death, life-threatening experience, in-patient hospitalization or prolongation of existing hospitalization, a persistent or significant disability/incapacity or a congenital anomaly/birth defect, or important medical event that might not be immediately life-threatening or result in death or hospitalization but might jeopardize the patient or might require intervention to prevent one of the other outcomes listed in the definition above

Based on published case reports, no

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This comes up constantly, so the short answer is: no, not in any targeted or meaningful way