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Description
Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors

By doubling your injection, you effectively create a sudden, substantial increase in drug concentration that your body has not been gradually adjusted to tolerate

The answer may lie in your DNA
If your weight loss includes muscle (and for many athletes, it does), the net effect can be neutral or even negative

References Ferencz C
