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The remaining 158,349 patients who did not use GLP-1 RAs were enrolled as the GLP-1 RAs non-users group

In expanded populations, comparing semaglutide versus sitagliptin for the composite outcome of myocardial infarction or stroke yielded a hazard ratio of 0.82 (95% confidence interval (CI) 0.74 to 0.91), and comparing tirzepatide versus dulaglutide for the composite outcome including mortality yielded a hazard ratio of 0.87 (95% CI 0.75 to 1.01)

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Because tirzepatide directly affects hormonal signaling and metabolic function, proper dosing, gradual titration, and ongoing medical guidance by registered nurses are essential for safety, comfort, and long-term success