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in Cell Metabolism (2020), tirzepatides dual agonist action enhances glucose-dependent insulin secretion from pancreatic beta cells, reduces glucagon secretion from alpha cells, and slows gastric emptying

Most commercial plans require prior authorization and step therapy

Putting This Into Practice Track your blood glucose patterns for 2 weeks before starting either medication to establish baseline variability and identify problematic time points

Avoid high-fat foods, high-fiber foods, caffeine, artificial sweeteners, and alcohol until symptoms improve

Water-rich foods, such as vegetables, fruits, yogurt, and broth-based soups, also contribute to your overall fluid intake