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The next level is now reached with retatrutide that stimulates all three above mentioned receptors (Coskun et al

In the pancreas, it enhances insulin secretion while suppressing inappropriate glucagon release, but only when blood glucose levels are elevated

Ludvik B, Giorgino F, Jodar E, Frias JP, Fernandez Lando L, Brown K, Bray R, Rodriguez A (2021) Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial

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