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Short-term treatment approachesusing Zepbound for several months to achieve initial weight loss, then discontinuinggenerally result in weight regain and loss of metabolic benefits

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Hypoxia induces the stabilization of the transcription factors hypoxia-inducible factor-1 (HIF-1) and HIF-2 which is influenced by O 2 -regulated proteins such as prolyl-hydroxylases (PHDs) and factor-inhibiting HIF (FIH) [21]