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In order to make GLP-1 better used in the clinic, drug developers modified its structure and developed a series of GLP-1R agonists ( GLP-1, a 30- or 31-amino-acid-long peptide hormone, is a gastrointestinal peptide secreted by the intestinal tract that potentiates insulin release and reduces glucagons concentration in physiological conditions ( Scheme 1

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Jamal M, Alhashemi M, Dsouza C, et al

A slightly warmed semaglutide dose (room temperature) combined with slow, steady injection pressure can reduce needle-site pain and bruising compared to cold injections

In unselected NSCLC populations, anti-PD-1/PD-L1 monotherapy yields objective response rates below 20%, and outcomes are even poorer in patients with epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) alterations
