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As a disorder in the way glucose is managed, insulin resistance even within normal AGEs levels must be niped on the but, otherwise progression is inevitable under the current standard western diets, leading to typical comirbidities

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Short answer, the one that matters: no meaningful human signal, the thyroid black box is a rodent-dose precaution (the same way the old estrogen black box was more politics than data), and we actually see lower rates of some cancers in people taking them

(A) Activation of SIRT by activator leads to deacetylation of Lys48 residues on LKB1

Diabetes Care 2009