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Compounded semaglutide is not FDA approved, and quality and efficacy can vary, but when its purchased through the right clinic and compounding pharmacy, the making of the product is still heavily regulated to ensure safety

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The three-way comparison of semaglutide, tirzepatide, and retatrutide shows that retatrutide may produce even greater weight loss than tirzepatide, but it is not yet FDA-approved and is only available through research sources