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Recognising Red Flag Digestive Symptoms and When to Seek Emergency Care When gastrointestinal distress becomes dangerous: dehydration, severe vomiting, and bleeding Persistent vomiting that prevents you from keeping fluids down can cause dehydration, electrolyte imbalance, and fainting

The reaction is local, not systemic

You sleep through the peak GLP-1 activation and wake up feeling relatively normal

Disproportionality Analysis Among all the 137583 PTs involving 26 SOC categories, significant SOCs related to tirzepatide which met at least one of the four algorithms were Injury, poisoning and procedural complications (SOC:10022117, n = 39065, ROR = 2.63), General disorders and administration site conditions (SOC:10018065, n = 34930, ROR = 1.62), Gastrointestinal disorders (SOC: 10017947, n = 26395, ROR = 2.66), and Metabolism and nutrition disorders (SOC:10027433, n = 4551, ROR = 1.77) ( Table S3 )

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