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100 , 101 While oral formulations have demonstrated acceptable tolerability overall, gastrointestinal side effects remain common and may occur at similar or slightly higher rates than with injectable agents

The risks of diarrhea was significantly higher for JNJ-64565111, Exenatide, Liraglutide, Orforglipron and Tirzepatide than for placebo, with Orforglipron having an RR of 5.56

Chubb B, Gupta P, Gupta J, Nuhoho S, Kallenbach K, Orme M

This bridging approach can help maintain appetite control while the tirzepatide dose decreases
