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doi:10.1016/j.biopha.2023.115281 211

The expanding role of GLP-1 receptor agonists

Gut microbiota-derived metabolites, such as short-chain fatty acids (SCFAs), tryptophan metabolites, and immune stimulants, are likely mediators in this process [85]

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The mechanism may involve protein kinase A and AMP-activated kinasemediated inhibition of acetyl-CoA carboxylase, resulting in decreased malonyl-CoA levels and increased mitochondrial entry of FAs and -oxidation
