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Decara J, Rivera P, Arrabal S, Vargas A, Serrano A, Pavn FJ et al (2018) Cooperative role of the glucagon-like peptide-1 receptor and 3-adrenergic-mediated signalling on fat mass reduction through the downregulation of PKA/AKT/AMPK signalling in the adipose tissue and muscle of rats

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ZP-6590 in combination with semaglutide produced mean weight losses of around 25% after 34 days in mice
In T2D, loss of the suppressive effects of glucagon and insulin is associated with hyperglucagonaemia and this is thought to contribute to hyperglycaemia (4750)

Moschovaki Filippidou F, Kirsch AH, Thelen M, Ketszeri M, Artinger K, Aringer I, et al
