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You have persistent vomiting or diarrhoea : These symptoms, especially if accompanied by reduced urine output, could lead to dehydration and acute kidney injury, requiring prompt medical attention

Journal reference: Pearson, J

Further research has found that these rates may be even higher in the real world, especially for people with obesity taking semaglutide or other GLP-1s for weight loss

A patient's genetic profile in these pathways may provide context for expected response strength and side-effect susceptibility, though genetics does not determine medication outcome alone

Note: If you experience leg pain that is localized to one side, involves significant swelling, or does not resolve with stretching and hydration, consult a licensed healthcare professional immediately