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In the past ten years, a series of Phase III trials showed that the synthetic GLP-1/GIP agonists are effective in lowering blood sugar in type 2 diabetic subjects who were both treatment-nave or on typical first-line therapies such as metformin and insulin
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While diabetic ketoacidosis (DKA) is rare in type 2 diabetes with adequate insulin production, uncontrolled blood sugar increases the risk of both acute complications and long-term microvascular and macrovascular damage
