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SURPASS-4 evaluated the safety of tirzepatide in a high cardiovascular risk population with advanced T2DM for a duration of 2 years [14]

The results of this rodent study showed superior glycemic control effects compared to cotadutide and liraglutide with greater weight loss compared to liraglutide, but similar to the cotadutide [70]

Because the drug clears so slowly, it may take a week or more for side effects to begin subsiding significantly

Other factors may include increased tear evaporation caused by wind, smoke, dry air, infrequent blinking, or eyelid problems

Conclusion The study found that GLP-1RA therapy is effective not only in managing blood glucose levels in individuals with type 2 diabetes but also in reducing body weight in obese individuals and changing unhealthy eating tendencies, such as the tendency to eat in response to external food cues (external eating)