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Both ligands had similar cAMP potency but the exendin-4-C16 showed 2.5-fold bias towards G protein recruitment and a 60% reduction in -arrestin-2 recruitment efficacy compared to exendin-4, as well as reduced GLP-1R endocytosis and preferential targeting towards recycling pathways

If it does the same job as the brand-name drug, its a copy

We ask experts for their views on the GLP-1 market in this exclusive eBook.

GLP-1 medications may offer benefits beyond weight loss and diabetes management, including better outcomes for breast cancer patients who are obese or have type 2 diabetes, according to new research.

This review will outline the physiology and pharmacological potential of amylin and GLP-1, respectively, and focus on innovative peptide drug development leading to drugs acting on two or more distinct receptors, such as an amylin and GLP-1 peptide hybrid, potentially producing a more effective treatment strategy to combat the rapidly increasing global obesity.