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Therefore, results of observational studies should be verified through the analysis of data from randomized trials

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However, their effectiveness can vary, and healthcare providers consider factors like co-existing health conditions before prescribing them

After a review of currently available data, the US Food and Drug Administration (FDA) and the European Medicines Agency agreed that there was insufficient evidence to confirm an increased risk of pancreatitis and pancreatic cancer with use of GLP-1-based therapies [104]