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RGC was reported in 17 (19%) of the GLP-1RA users as compared to 5 (5%) of the non-users, with an associated adjusted odds ratio (OR) increased by almost 6-fold (5.8 with 95% confidence interval [95% CI]: 1.719.3, P = 0.004)

Why have GLP-1 receptors historically been difficult to target with small molecules, and what has changed to make oral versions possible now

Trulicity is a dulaglutide injection drug used to treat diabetes and cardiovascular disease and help people lose weight (off label)

While effective at achieving and maintaining weight loss, long-term use of incretin mimetics is likely needed to maintain weight since weight regain is common following drug discontinuation, with a return to baseline within a year 12,13

As the scientific community continues to unravel the mysteries of GLP-1, it may very well be the key to unlocking healthier, happier lives for many individuals.