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Retatrutides broader trial program has reported additional findings beyond weight loss: the TRIUMPH-4 trial recorded meaningful reductions in knee osteoarthritis pain among participants with obesity, and a nested substudy of TRIUMPH-1 reported a 60.6% reduction in the apnea-hypopnea index in participants with obstructive sleep apnea

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Interestingly, lower levels of branched-chain amino acids (BCAAs) and keto acids in the blood have been linked to the effect of tirzepatide and LAGIPRA on insulin sensitivity