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Tirzepatide alone delivers superior sustained weight loss (1522% at maintenance) without the tolerance fade that limits phentermine to 12 weeks

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For context, the current NICE guidance for semaglutide (TA875) requires BMI 35 kg/m with comorbidities, or BMI 40 kg/m without, plus specialist weight management service referral

This activation triggers several physiological responses that can contribute to weight loss: Appetite regulation: Semaglutide helps reduce appetite and increase feelings of fullness (satiety)