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But there is some evidence in people without diabetes: Metformin has been studied in diabetes-prevention trials and in people with insulin resistance, PCOS, and higher BMIs

Most patients use it for 3 to 12 months, depending on goals

Talk to your provider if this is happening repeatedly

Cost-effectiveness of semaglutide in people with obesity and cardiovascular disease without diabetes

37 However, the invasive nature of endoscopy often causes physical pain as well as psychological stress to patients
