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Elkind-Hirsch K, Marrioneaux O, Bhushan M, et al

administration of exendin-4 into the 4th ventricle reduces food intake via reduction of meal frequency

Novo Nordisks Response to JAMA Study and Allegations In an emailed statement, Wegovy manufacturer Novo Nordisk countered that there were several limitations of the JAMA study design, which was not a randomized controlled trial, as reported by Reuters

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Mechanistically, these neuroprotective effects are underpinned by the activation of canonical GLP-1 R signaling pathways within the retina