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As a small molecule, it is resistant to digestive degradation, easily absorbed through the intestinal wall (79% bioavailability), and can be manufactured using conventional chemical synthesis at a fraction of the cost of peptide production

Additionally, some individuals may experience side effects such as nausea or diarrhea

Hypokalaemia (low potassium) is clinically significant as it can cause dangerous cardiac arrhythmias, especially in patients taking diuretics, ACE inhibitors, or other medications affecting electrolyte balance

Even tissues with relatively low GLP-1R expression, such as the liver and intestinal epithelium, can benefit indirectly through systemic metabolic improvements and paracrine signaling, as evidenced in conditions like NAFLD and inflammatory bowel disease (IBD) [56, 57]

The SURPASS trials evaluated its efficacy for type 2 diabetes