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Description
Specifically, we showed that GLP-1R activation leads to receptor segregation into flotillin-positive lipid nanodomains and that disruption of the plasma membrane architecture by cholesterol extraction with methyl--cyclodextrin (MCD) significantly reduces exendin-4-mediated receptor clustering, internalisation, and cAMP accumulation in beta cells (25)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 2.Ryan D, Acosta A
