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By identifying whether a patient carries variants associated with reduced GLP1R expression or altered GIPR signaling, providers can frame realistic expectations about dose escalation timelines and assist in choosing between single-peptide (semaglutide) and dual-peptide (tirzepatide or GLP-Squared) formulations

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Most insurance plans do not cover weight loss drugs so it is recommended to speak to your insurance provider or check the formulary to verify if weight loss drugs including Zepbound are covered