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The mechanism by which GLP-1RAs induce reduction of body weight and hunger is believed to relate to multiple mechanisms by which GLP-1 regulates appetite and energy consumption and supports metabolic homeostasis via central neuronal pathways and through neuronal activation in the gastrointestinal tract [94, 141]

Diabetes Med (2011) 28(11):135261

During the consultation, we will review the patients medical history, including any underlying medical conditions, medications, and lifestyle factors, to determine whether GLP-1 is a suitable treatment option We will explain how the medication works, its potential benefits and risks, and any lifestyle changes that will be necessary to optimize the treatment outcomes

Consistent with this, exendin-4 decreased NHE3-mediated sodium-dependent pH recovery in porcine kidney LLC-PK 1 cells [771]
