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Mansoor Husain has received research grants from AstraZeneca, Merck, and Novo Nordisk, and advisory/consultancy fees from AstraZeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Merck, Novo Nordisk, and Roche
Nomiyama, T., Kawanami, T., Irie, S., Hamaguchi, Y., Terawaki, Y., Murase, K., Tsutsumi, Y., Nagaishi, R., Tanabe, M., Morinaga, H., et al
In the brain, particularly the hypothalamus and brainstem, they reduce appetite and increase satiety signals
However, there are on the horizon no cardiorenal outcome studies comparing SGLT-2 inhibitors with GLP-1RA, so it is likely that we must rely on indirect comparisons
Each compound has been studied on its own, but the combination has not been tested in any trial
