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Over months and years, this pattern increases diabetes risk significantly beyond what weight alone would predict

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Appetite is still reduced but more predictable
For example, specific symbiotic bacteria activate the Nrf2/ARE pathway through the secretion of metabolites such as short-chain fatty acids (SCFAs), thereby upregulating antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GPx), to effectively scavenge excessive ROS and enhance the integrity of the intestinal epithelial barrier [9]
