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Side effects may include nausea, low blood sugar, pancreatitis, and increased heart rate, among others
The surface of some cells in the pancreas, gut, and brain contain this receptor
10.1093/toxsci/kfx018 291
Evidence comes from large-scale studies such as the SCALE and LEAD trials for liraglutide, the STEP 18 program for semaglutide, the SURMOUNT 14 trials for tirzepatide, AWARD-11 for dulaglutide, and DURATION-1 for exenatide (Table 3)
This altered gastric emptying can modify the entire digestive process, affecting how quickly food is broken down and absorbed throughout the gastrointestinal tract
