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Emerging studies are exploring the potential of GLP-1-based therapies in diverse populations and comorbidities, such as patients with type 2 diabetes or cardiovascular diseases

metformin, sulfonylureas, TZDs, etc.) address only one of the underlying pathophysiology - lowering postprandial glucose levels, but their safety profiles and side effects, such as weight gain and hypoglycemia, may present challenges and limitations in their clinical use

Cellular and molecular mechanisms of metformin: an overview

It's important in a number of different ways

Furthermore, it slightly reduced the increase of glucose transporter types 1 and 4 (GLUT1/4) during adipogenesis and led to a rise of GLP-1 mRNA, though protein levels remained unchanged