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The digestive system is already under significant stress and inflammation

2 3 4 Because insulin resistance sits at the mechanistic center of PCOS for the majority of affected women, there is a coherent, biologically plausible hypothesis that retatrutide would help

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GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R

Blood glucose monitoring may be advisable for patients taking GLP-1 medications alongside insulin or sulfonylureas, as these combinations increase hypoglycaemia risk
