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The brain is remarkably sensitive to peptide signaling, which is why fatigue can be such a prominent early effect of GLP-1 agonist therapy

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A second double-blind, placebo-controlled, randomized, crossover design, analog classroom study (Study 3) was conducted in pediatric patients ages 6 to 12 years (N=129) who met DSM-IV criteria for ADHD (either the combined type or the hyperactive-impulsive type)

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