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These letters concern a television show featuring Oprah Winfrey that aired in 2024, which contained false and misleading claims about Novo Nordisks Ozempic, Wegovy, and Victoza, and Eli Lillys Mounjaro and Zepbound products

The brain is remarkably sensitive to peptide signaling, which is why fatigue can be such a prominent early effect of GLP-1 agonist therapy

Snacking can be due to a habit rather than being hungry

In clinical trials, patients lost an average of 10-15% of body weight over 68 weeks
A second double-blind, placebo-controlled, randomized, crossover design, analog classroom study (Study 3) was conducted in pediatric patients ages 6 to 12 years (N=129) who met DSM-IV criteria for ADHD (either the combined type or the hyperactive-impulsive type)