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Interestingly, treatment of mouse cardiomyocytes with GLP-1 936 amide (a GLP-1 degradation product in vivo) resulted in Akt activation, extracellular regulated kinase (ERK) phosphorylation, and reduced apoptosis induced by hypoxia or hydrogen peroxide stress, implying an unconventional action of GLP-1 (Ban et al., 2010)

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The most commonly reported adverse effects are gastrointestinal in nature , affecting a significant proportion of patients, particularly during the initial weeks of treatment or following dose escalation
This alarming trend has led to a heightened demand for effective pharmacological interventions, particularly GLP-1 receptor agonists, which have demonstrated efficacy in weight loss and glycemic control
