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Importantly, they can also convert indigestible carbohydrates into short-chain fatty acids (SCFA), which in turn activate specific G protein-coupled fatty acid (FFA) receptors, thereby promoting the secretion of peptide hormones from the enteroendocrine cells [106, 107]

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Not all peptide systems share these properties, and some may fail due to genuine on-target toxicity that cannot be mitigated solely through pharmacologic engineering

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[1] [2] This combination of effects leads to improved glycaemic control and, in many patients, significant weight loss