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The SUSTAIN-6 trial demonstrated that semaglutide reduced major cardiovascular events in high-risk diabetic patients, an effect not attributable to metformin monotherapy
= 1.0) in the placebo group
As como GLP-1 es tambin clivado rpidamente por la enzima DPP-4 (60)
doi: 10.1016/j.tem.2012.11.008
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