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Retatrutide onset appears comparable, with most researchers observing initial effects within similar timeframes

GI side effects are worst during dose escalation (weeks 116) and improve significantly once maintenance dose is reached

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This creates a growth opportunity to develop functional and medical nutrition products that help boost wellness through reduced food intake

This is relevant as weight loss following caloric restriction has been reported to influence gut microbiome composition in DIO mice, although the implications are poorly understood 33,79