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Concomitantly, autophagy was reported to also reduce the hepatocyte apoptosis caused by steatosis and endoplasmic reticulum stress, possibly through the GLP-1RA-stimulated GLP-1R-mediated activation of the EB transcription factor of the autophagy-lysosome pathway, thus reducing the accumulation of liver lipids (201)

Clinical trials showed modest results, and AOD-9604 was not pursued through full FDA drug approval

Comprehensively prognostic and immunological analyses of GLP-1 signaling-related genes in pan-cancer and validation in colorectal cancer