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Patient Safety Continuing appetite-suppressing medication at very low BMIs may increase the risk of: Excessive or unintended weight loss Nutritional deficiencies Lean muscle loss Hormonal disruption Disordered eating patterns The BMI 22 kg/m threshold acts as a safety boundary

PLoS ONE 8 , e69824 (2013)

And: "findings provide multi-layered genetic evidence supporting a structured and locus-specific shared genetic architecture between IBD and several psychiatric disorders
