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Researchers specifically targeting visceral and hepatic fat may find this advantage decisive in their compound selection
Nevertheless, the study certainly supports the notion that increased secretion of GLP-1 following GB surgery, together with other mechanisms including secretion of other enteric hormones, quicker passage of food through the small bowel, reduction in liver fat, and weight loss in general, may all play a role in the substantial glycemic improvements seen with GB surgery in patients with type 2 diabetes

Image Credit: Gecko Studio / Shutterstock In a recent review published in The Lancet , researchers synthesized decades of research on incretin-based medications

This leads to delayed gastric emptying, where food remains in the stomach for an extended period

However, GLP-1 analogs have been manufactured to be resistant to the effects of DPP-4 and renal clearance and are shown to be effective in the treatment of type-2 diabetes
