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How GLP-1 Works: GLP-1 is a natural gut hormone that helps you feel full and supports metabolism

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The 0.25mg starting dose of semaglutide triggers meaningful weight loss in most patients within the first 4-8 weeks

While weight management is important in IBD, GLP-1 medications demand individualized provider assessment of inflammatory status, current therapies, and potential pancreatitis or bowel

When cultured human L-cells were deprived overnight of glucose and serum and then exposed to high glucose, 10% FBS, and -carrageenan (1g/ml) for 10minutes, 1h, and 24h, mRNA expression of proglucagon and secretion of GLP-1 were significantly reduced, compared to control cells not exposed to carrageenan