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Additionally, dietary protein-derived metabolites, including tryptophan-indole, as well as LPS from Gram-negative bacteria, directly promote the production of GLP-1 (66, 67)

Blood glucose monitoring may be advisable for patients taking GLP-1 medications alongside insulin or sulfonylureas, as these combinations increase hypoglycaemia risk

Each dose increase typically occurs at 4-week intervals , allowing adequate time to assess tolerance

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GLP-1 has a central anorexigenic effect via the reduction of appetite and energy intake, as well as increased satiety [24]