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Results The MR analyses suggested genetically proxied GLP-1R-based agonists were causally associated with a reduced risk of MASLD (GIPR/GLP-1R agonist: OR: 0.17, 95%CI: 0.050.52, P = 2.07 10 3

Improved glycaemic control from GLP-1 therapy may reduce diabetes-related fatigue caused by fluctuating blood glucose levels

However, continuous research and vigilant monitoring are essential to optimize their safe use [55] [56], particularly as these medications are used in broader populations for longer durations

For individuals who cannot tolerate weight loss injections after cholecystectomy, or for whom they are unsuitable, several evidence-based alternatives exist within NHS pathways